Depression is a serious mental disorder characterized by alteration in mood, loss of interest and feeling sad, irritable, and empty. World Health Organization ranks depression as the leading cause of mental disability and is projected to become top contributor to the global disease burden by 2030. The pathogenesis of depression is very diverse, complicated, and unclear.

**О чём работа:** Depression is a serious mental disorder characterized by alteration in mood, loss of interest and feeling sad, irritable, and empty. World Health Organization ranks depression as the leading cause of mental disability and is projected to become top contributor to the global disease burden by 2030. The pathogenesis of depression is very diverse, complicated, and unclear.

**Ключевые акценты:** - депрессия - антидепрессанты - молекулярные мишени - сигнальные пути - воспаление

**Почему это важно:** Работа систематизирует направления, которые могут лечь в основу более персонализированных и биомаркер‑ориентированных подходов в психиатрии.

**Связанные публикации:** - https://psync.ru/articles/pmid-42435876/ — complements: общие понятия: воспаление, депрессия - https://psync.ru/articles/pmid-42419634/ — complements: общие понятия: воспаление, депрессия

**Источник:** https://doi.org/10.3389/fcell.2026.1762930 https://pubmed.ncbi.nlm.nih.gov/42435254/