Психофармакология Нейробиология и нейрохимия Общая и биологическая психиатрия

Brain-targeted epigenetic effects of two emerging psychoplastogens: ketamine & MDMA.

Теги
кетамин МДМА эпигенетика психопластогены нейропластичность
Psychoplastogen compounds such as ketamine and MDMA have shown therapeutic promise for mood and trauma-related disorders, yet the molecular mechanisms underlying their effects remain poorly understood. Here, we applied a Brain-Epigenome-Wide Association Study (BEWAS) targeting brain-relevant genes to examine DNA methylation changes following treatment. Pre- and post-treatment blood (ketamine, N = 20) and saliva (MDMA, N = 16) samples were collected from clinical trial participants.

**О чём работа:** Psychoplastogen compounds such as ketamine and MDMA have shown therapeutic promise for mood and trauma-related disorders, yet the molecular mechanisms underlying their effects remain poorly understood. Here, we applied a Brain-Epigenome-Wide Association Study (BEWAS) targeting brain-relevant genes to examine DNA methylation changes following treatment. Pre- and post-treatment blood (ketamine, N = 20) and saliva (MDMA, N = 16) samples were collected from clinical trial participants.

**Ключевые акценты:** - кетамин - МДМА - психопластогены - эпигенетика - нейропластичность

**Почему это важно:** Работа систематизирует направления, которые могут лечь в основу более персонализированных и биомаркер‑ориентированных подходов в психиатрии.

**Источник:** https://doi.org/10.1038/s41398-026-04191-3 https://pubmed.ncbi.nlm.nih.gov/42436129/