Нейробиология и нейрохимия Социальная психиатрия Общая и биологическая психиатрия

Calcium signaling pathway implicates a shared genetic basis between psychiatric and cardiovascular diseases.

Zhu Y · Zhao G · Zhang Y

Опубликовано 01 Июл 2026

Время чтения 1 мин

Теги

Psychiatric and cardiovascular diseases (CVDs) are frequently comorbid and are interconnected through the brain-heart axis. However, the underlying shared genetic etiology remains unknown in East Asians. To address this critical gap, we conducted a genome-wide pairwise trait pleiotropy study by leveraging genome-wide association studies of three major psychiatric disorders (schizophrenia [SCZ], bipolar disorder [BIP], major depressive disorder [MDD]) and ten cardiovascular traits (including e...

**О чём работа:** Psychiatric and cardiovascular diseases (CVDs) are frequently comorbid and are interconnected through the brain-heart axis. However, the underlying shared genetic etiology remains unknown in East Asians. To address this critical gap, we conducted a genome-wide pairwise trait pleiotropy study by leveraging genome-wide association studies of three major psychiatric disorders (schizophrenia [SCZ], bipolar disorder [BIP], major depressive disorder [MDD]) and ten cardiovascular traits (including e...

**Ключевые акценты:** - кальциевый сигналинг - генетика - психические расстройства - сердечно‑сосудистые заболевания - плейотропия

**Почему это важно:** Работа систематизирует направления, которые могут лечь в основу более персонализированных и биомаркер‑ориентированных подходов в психиатрии.

**Источник:** https://doi.org/10.1038/s41398-026-04222-z https://pubmed.ncbi.nlm.nih.gov/42436150/