Психофармакология Клинические исследования Общая и биологическая психиатрия

Psilocybin-induced behavioral and cellular effects.

Теги

Psilocybin, a prominent psychedelic, recently emerged as a potential therapeutic agent for psychiatric disorders, yet the molecular and cellular mechanisms driving its effects remain poorly understood. To address these knowledge gaps, we focused on the nucleus accumbens (NAc), a forebrain region that regulates reward, motivation, and emotion. Systemic administration of psilocybin (3 mg/kg) induced a rapid inhibition of mouse locomotor activities, which was resolved by ∼1 h post-psilocybin tre...

**О чём работа:** Psilocybin, a prominent psychedelic, recently emerged as a potential therapeutic agent for psychiatric disorders, yet the molecular and cellular mechanisms driving its effects remain poorly understood. To address these knowledge gaps, we focused on the nucleus accumbens (NAc), a forebrain region that regulates reward, motivation, and emotion. Systemic administration of psilocybin (3 mg/kg) induced a rapid inhibition of mouse locomotor activities, which was resolved by ∼1 h post-psilocybin tre...

**Ключевые акценты:** - псилоцибин - серотониновые рецепторы - нейропластичность - поведение - клеточные эффекты

**Почему это важно:** Работа систематизирует направления, которые могут лечь в основу более персонализированных и биомаркер‑ориентированных подходов в психиатрии.

**Источник:** https://doi.org/10.1080/01677063.2026.2695462 https://pubmed.ncbi.nlm.nih.gov/42437560/